def twos_compliment(byte_arr): a = byte_arr[0]; b = byte_arr[1]; c = byte_arr[2] out = ((a<<16)&0xff0000) | ((b<<8)&0xff00) | (c&0xff) neg = (a & (1<<7) != 0) # first bit of a is the "signed bit." if it's a 1, then the value is negative if neg: out -= (1 << 24) print hex(a), hex(b), hex(c), neg, out return out # 1234567 twos_compliment([0b00010010, 0b11010110, 0b10000111]) # -1234567 twos_compliment([0b11101101, 0b00101001, 0b01111001]) # 7654321 twos_compliment([0b01110100, 0b11001011, 0b10110001]) # -7654321 twos_compliment([0b10001011, 0b00110100, 0b01001111])
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